BREAST CANCER OVERVIEW
Breast cancer is the most common female cancer in the United States. Finding and treating breast cancer in the early stages allows many women to be cured.
This article will focus on the surgical treatment of breast cancer. An introduction to breast cancer and an overview of treatment for breast cancer are also available.
BREAST CANCER STAGING
In addition to removing the cancer from the breast and lymph nodes, surgery also provides important information about the “stage” of the cancer. The anatomic stage of breast cancer is based upon the size of the tumor in the breast (T), presence of cancer in the lymph nodes (N), and metastatic spread to distant sites (M). The prognostic stage also depends upon additional information, such as tumor grade and the expression of biomarkers, including estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2).
Staging of breast cancer is discussed in detail in a separate article
FACTORS AFFECTING SURGICAL TREATMENT
Several factors must be considered when choosing the best surgical treatment for your breast cancer. You should discuss these factors with your health care provider as you decide which treatment is best for you.
Microscopic findings — The surgeon must determine if a breast cancer is invasive or non-invasive (in situ).
Invasive breast cancer — Invasive breast cancers usually require surgical treatment (mastectomy or breast-conserving therapy) as well as treatment after surgery (called adjuvant treatment). Adjuvant treatment can include radiation as well as systemic treatment such as chemotherapy or endocrine therapy.
Noninvasive (in situ) breast cancer — Noninvasive or in situ breast cancer is divided into two types: lobular carcinoma in situ (LCIS) and ductal carcinoma in situ (DCIS).
●LCIS – Although LCIS is often described as non-invasive breast cancer, it is not a cancerous or even precancerous lesion and does not require treatment. However, the presence of LCIS on a breast biopsy is associated with an increased risk of developing breast cancer over a lifetime, and patients are often counselled on risk reduction.
●DCIS – Women with DCIS require surgical treatment (mastectomy or breast-conserving therapy) and may require treatment after surgery (called adjuvant treatment). Adjuvant treatment can include radiation as well as systemic treatment such as endocrine therapy. Chemotherapy is usually not necessary.
Size of the breast tumor — Mastectomy may be needed for larger tumors, as lumpectomy may not be possible or produce the desired cosmetic outcome. However, sometimes patients with larger tumors can undergo chemotherapy prior to surgery, which is called neoadjuvant chemotherapy, and undergo breast-conserving surgery if the tumor shrinks.
Tumors that invade the skin or muscle and inflammatory breast cancers also require chemotherapy, and mastectomy is usually recommended for these more advanced cancers. This is discussed in a separate article. (
Spread to the lymph nodes — Lymph nodes are usually the first place for breast cancer to spread. If a breast cancer has spread to lymph nodes, it is called node positive; a cancer that has not spread to the lymph nodes is called node negative. If a breast cancer has spread to the lymph nodes, it is more likely to recur.
SURGICAL TREATMENT
Surgical removal of the tumor is often the first step in treating early-stage breast cancer. However, systemic treatment (eg, chemotherapy, targeted therapy, or endocrine therapy) may be recommended before surgery for some type of breast cancer, or for larger or more advanced tumors.
There are two options for breast surgery:
●Mastectomy involves removing the entire breast.
●Breast-conserving surgery removes just the cancerous area and a small amount of surrounding normal tissue (also called lumpectomy). Breast-conserving surgery plus radiation therapy is referred to as breast-conserving therapy or BCT.
In centers that specialize in breast cancer treatment, approximately 75 percent of women with early-stage breast cancer are candidates for BCT. In 25 to 50 percent of women, there are medical, cosmetic, and/or social and emotional reasons for having a mastectomy rather than BCT. Survival outcomes are the same whether BCT or mastectomy is performed.
MASTECTOMY
Mastectomy may be recommended because of the location of your tumor, the size or shape of your breast, findings on your imaging examinations (mammogram or magnetic resonance imaging [MRI]), or whether radiation may be used. Mastectomy may also be your preference.
Simple mastectomy — A total or simple mastectomy involves removing the entire breast without removing the axillary lymph nodes. A technique called sentinel lymph node biopsy is performed to be sure that the cancer has not spread to the lymph nodes.
Skin-sparing mastectomy — In a skin-sparing mastectomy, the nipple and areola are usually removed, but the rest of the skin over the breast is preserved. This is done in conjunction with immediate reconstruction with a plastic surgeon.
Nipple-sparing mastectomy and areola-sparing mastectomy — Because there is breast tissue extending to the nipple-areolar complex (NAC), standard mastectomies (both simple and skin-sparing) usually involve removing the NAC. However, for certain subsets of patients, it may be safe to preserve either the entire NAC (the nipple-sparing mastectomy, NSM) or remove the nipple with the breast tissue but preserve the areola (areola-sparing mastectomy, ASM). As with the skin-sparing mastectomy, these are done in conjunction with immediate reconstruction with a plastic surgeon.
Modified radical mastectomy — During a modified radical mastectomy (MRM), the breast tissue and the lymph nodes in the armpit (the axillary lymph nodes) are removed. An axillary node dissection is necessary only if the cancer has spread to the lymph nodes.
Contralateral prophylactic mastectomy — Some women undergoing mastectomy may opt to have the opposite (uninvolved) breast removed as well. This is done to reduce the risk of a subsequent new breast cancer, particularly in women at an elevated risk of second breast cancers (such as those with a strong family history or a known genetic mutation).
Breast reconstruction — Reconstruction of the breast is an important option for women who undergo mastectomy. You may choose to have breast reconstruction immediately after the mastectomy or at a later time. The nipples may also be reconstructed to allow the breast to appear more natural. There are several options for reconstruction, and all women planning to undergo mastectomy should see a plastic or reconstructive surgeon to discuss these options before having breast surgery.
Complications of mastectomy — Mastectomy is generally a safe surgery, although complications can occur, including bleeding, pain, infection, or a persistent collection of fluid beneath the skin. (
Radiation therapy after mastectomy — Radiation therapy is sometimes recommended after a mastectomy to decrease the chance of a recurrence, especially in women who have locally advanced cancer, who have close or positive margins after mastectomy, or who have positive lymph nodes.
More information about radiation therapy is available below.
BREAST-CONSERVING THERAPY (BCT)
Breast-conserving therapy refers to surgical removal of the tumor and a small portion of normal surrounding breast tissue. BCT is often followed by radiation therapy to the remaining breast tissue. Breast-conserving surgery is also called a partial mastectomy or lumpectomy
Radiation therapy
Invasive breast cancer — Radiation therapy (RT) refers to the exposure of a tumor to high-energy X-rays in order to slow or stop its growth. Exposure to X-rays damages cells. Unlike normal cells, cancer cells cannot repair the damage caused by exposure to X-rays over several days. This prevents the cancer cells from growing further and causes them to eventually die.
RT for breast cancer is mostly given as external beam RT, meaning that the radiation beam is generated by a machine that is outside the patient. Exposure to the beam typically takes only a few seconds (similar to having an X-ray). In some patients, RT is given daily, five days per week, for approximately five to six weeks; in others, RT is given over three weeks. Some patients may be candidates for an accelerated course of RT, which is only given to the part of the breast where the cancer was removed. This is called “accelerated partial breast irradiation” and can be performed with either external beam RT or by placing a catheter within the space where the tumor was and delivering the radiation from the inside (“brachytherapy”).
Radiation is generally recommended for most women who have had breast-conserving surgery for invasive breast cancer, even if the tumor is very small. The goal of this treatment is to kill any remaining cancer cells. Some women, such as those who are over 65 and have hormone-receptor positive cancer, may be safely treated without radiation.
In situ breast cancer — Some women with ductal carcinoma in situ (DCIS) will be advised to have radiation therapy after breast-conserving surgery. This will depend on the size and grade of the DCIS, your age, the margins, and whether the DCIS is hormone receptor positive.
Cosmetic outcomes — With modern surgical techniques, cosmetic results are good to excellent in most women after breast-conserving therapy (ie, the treated and untreated breast are almost identical or there are only slight differences). The effects of BCT on the appearance of the breast take about three years to stabilize. Factors such as weight gain and the normal age-related sagging of breast tissue also affect the shape and size of the breasts.
Complications following BCT — Following breast-conserving surgery or radiation, complications can sometimes occur, including bleeding, pain, infection, or collection of fluid.
MASTECTOMY VERSUS BREAST-CONSERVING THERAPY
Studies show that women with localized breast cancer are equally likely to survive their cancer whether they are treated with BCT or a mastectomy [1,2].
Factors to consider — Although cancer outcomes are similar, there are several factors that you should consider when trying to decide between BCT and mastectomy.
●Tumor size – Some women who have a large tumor and small breasts are advised to undergo mastectomy rather than BCT. However, chemotherapy may be given before surgery to shrink the tumor; this may allow the woman to have breast-conserving surgery, if she desires it.
●Extensive DCIS – Extensive ductal carcinoma in situ (DCIS), an early cancer, does not respond well to chemotherapy and therefore may necessitate a mastectomy to make sure that all the disease is removed.
●Tumor margins – After lumpectomy, it is important to have a margin of normal breast tissue around the tumor. If cancer cells are found at or near the edges of the tissue removed, additional surgery may be necessary. If a large amount of tissue has been removed and the margins are still involved, mastectomy may be recommended.
●Need for radiation – For most women, BCT involves both lumpectomy and radiation. While radiation does allow for preservation of the breast, there are both immediate and long-term side effects. Mastectomy is often recommended in women who prefer to avoid radiation.
●Individual needs and preferences – You should discuss your preferences and concerns about preserving your breast with your doctor.
●Risk of a second breast cancer – Some women may be candidates for BCT but may be at an elevated risk of developing another breast cancer. These include noticeably young women, women with a strong family history of breast cancer (such as several family members with cancers at young ages or in multiple generations), or women with a known breast cancer gene mutation. These women are still candidates for BCT but may wish to undergo bilateral mastectomy to not only treat the known cancer but prevent a second cancer in the future.
Reasons to avoid BCT — Certain factors clearly favor mastectomy over BCT. These include:
●Multiple tumors – Having two or more separate tumors in different areas (quadrants) of the breast. Unless two tumors are close enough that they can be removed with one excision, mastectomy is recommended for women with more than one cancer in the breast.
●Extensive tumor – If tumor is spread throughout the breast tissue, it will not be possible to remove the entire tumor without a mastectomy.
●Contraindications to radiation – Some women are not candidates for radiation, such as women who are pregnant, who have already had radiation to the area, or with conditions that make radiation dangerous, such as scleroderma.
Factors that do not affect your decision — Several factors do not play a role in the choice between BCT and mastectomy:
●Age
●The spread of cancer cells to lymph nodes in the axilla
●The chance that breast cancer cells will metastasize or spread to other locations in your body
MANAGEMENT OF AXILLARY LYMPH NODES
Most women with invasive cancer will have an operation to check for cancer cells in the axillary lymph nodes. Women with ductal carcinoma in situ (DCIS) have a very small chance of having cancer cells spreading to the axillary lymph nodes. In general, sentinel lymph node biopsy (SLNB) is not recommended for women with DCIS unless a mastectomy is being performed. In that case, SLNB is done since, if invasive cancer is found in the mastectomy specimen, the surgeon cannot go back and do an SLNB procedure after a mastectomy.
Axillary lymph node dissection — This procedure involves removing most of the lymph nodes in the axilla (armpit). In the past, this was performed for all women with invasive breast cancer, but it can be associated with complications such as pain and lymphedema (arm swelling). An axillary lymph node dissection is now usually performed only for patients when cancerous lymph nodes can be felt in the axilla or when the sentinel lymph node excision reveals multiple nodes containing cancer or a large burden of cancer cells. An axillary lymph node dissection may also be recommended for women who still have cancer in the lymph nodes following neoadjuvant chemotherapy.
Sentinel lymph node definition — The sentinel lymph node is the first lymph node that receives lymphatic drainage from the breast. The sentinel node for patients with breast cancer is usually located in the axilla but in some patients may be near the sternum (breast bone) between the ribs (internal mammary lymph nodes). In addition, there may be more than one sentinel lymph node. Most patients do not have cancer in their sentinel lymph nodes.
Sentinel lymph node excision — A sentinel lymph node excision is performed to spare patients an axillary lymph node dissection when possible. It is based upon the finding that if the sentinel node does not contain cancer cells, the likelihood that other lymph nodes in the axilla contain cancer cells is very small [1].
To identify the sentinel lymph node, the surgeon injects blue dye or a radioactive material, or a combination of both, into the breast. The dye or radioactive material enters the lymphatic channels and flows to the sentinel lymph node, which helps the surgeon identify and remove the appropriate lymph nodes. The sentinel nodes are examined under the microscope by a pathologist.
If no cancer cells are identified in the sentinel node(s), then no further axillary surgery is needed. Today, most women with cancer in the sentinel node(s) also do not require any additional axillary surgery. However, some patients with positive sentinel lymph node(s) may be recommended to have an axillary dissection, depending on the number of involved nodes, the burden within the node, or whether they are planning to have radiation therapy
TREATMENT AFTER SURGERY
Treatment after surgery, called adjuvant treatment, is often recommended for women with invasive breast cancer. Adjuvant treatment is discussed in a separate article.
SURVEILLANCE AFTER INITIAL TREATMENT
After being treated for breast cancer, there is a risk that breast cancer may recur, or a new breast cancer may develop. Breast cancer survivors are advised to see their surgeon and/or medical oncologist every six months for an examination. Some patients may require examinations every three months, especially within the first three years. Your doctor will advise you on the appropriate follow-up schedule for you.
All patients treated for breast cancer are advised to perform a self-breast and chest wall examination monthly. Patients who have undergone a mastectomy with reconstruction should perform an examination of the reconstructed breast. Patients treated with a mastectomy without reconstruction should examine the chest wall. The self-examination for all patients should also include checking the lymph node areas. You should promptly call your doctor or nurse if you feel a new mass, see any redness of the skin not related to radiation treatments, or if you have any questions about your self-examination.
A yearly mammogram should be performed for all women who have undergone breast-conserving therapy or a unilateral mastectomy. In most instances, mammography after mastectomy and breast reconstruction is usually not recommended.
Source Credit: https://www.uptodate.com/contents/surgical-procedures-for-breast-cancer-mastectomy-and-breast-conserving-therapy-beyond-the-basics